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cultured insulin-sensitive human HepG2 cells under high-glucose conditions and administered cocoa-derived polyphenols and epicatechin, which blocked tyrosine phosphorylation and lowered total IR, IRS-1, and IRS-2 levels through PI3K/AKT and AMPK pathway inhibition, thereby mitigating high-glucose-induced insulin signaling impairment that alters gluconeogenesis (Isabel et al., 2014)
doi: 10.1212/01.wnl.0000203336.12114.09 100 LewisWCopelandWCDayBJ
Figure 3 Omega-3 fatty acids Among the nutritional intakes, fatty acids (FAs) have a crucial role in determining the composition of lipid-content cell membranes and even cell signaling molecules (124, 125)
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